EXPERIMENTAL IMMUNOLOGIC ADRENAL INJURY

Experimental Immunologic Adrenal Injury

Twenty-three unilaterally adrenalectomized guinea pigs were injected with autologous and homologous adrenal tissue homogenates respectively, in Freund's adjuvant. Widespread adrenal lesions were found in 10 of 12 animals receiving auto-antigen and to a lesser extent in 6 of 11 animals injected with homologous pooled antigen. Widespread systemic lesions were present in both these and in control ...

Immunologic mechanisms of parenchymal lung injury.

The lung, like most other organs, is susceptible to injury by circulating immune complexes, and also by humoral autoantibody and immune lymphocytes which specifically recognize selected lung antigens. In addition, by virtue of its direct communication with the external environment, the lung can also be injured by inhaled environmental agents which trigger inflammatory reactions mediated by immu...

Mechanisms of Immunologic Injury of Rat Peritoneal Mast Cells

The ability of a number of p-nitrophenylethyl, alkyl phenylalkyl, chloroalkyl, and aminoalkyl phosphonates to inhibit the homocytotropic antibody-mediated release of histamine from rat peritoneal mast cells has been tested. The effectiveness of these same phosphonates against the activated first component of rat complement (C'1a) has also been investigated. The rat mast cell esterase activated ...

Experimental granulomatous pneumonitis: immunologic, histologic, and ultrastructural correlations.

not significantly different from control animals suggesting that the total number of activated macrophages was small. Intratracheal inoculation with M faeni antigen resulted in the production of anti-M faeni precipitating antibodies in serum of all inoculated animals. Anti-M faeni precipitins demonstrated by counterimmunoelec-trophoresis were also found in 14 of 16 concentrated h g wash specime...

Mitochondrial Damage in Experimental Congenital Adrenal Hyperplasia